李陶，男，生于1957年，日本东京大学农业生物学博士，美籍华人。李陶博士在Science、Cell Stem Cell等国际学术刊物上发表30多篇原创论文，其中影响因子5.0以上的文章近20篇，在Science上发表的论文影响因子达到31.9，发明专利9项。

李陶，日本东京大学农业生物学博士，美籍华人。曾在日本岩手生物工学研究中心、美国斯坦福大学医学院担任研究员，现任深圳市干细胞工程技术研究开发中心主任、深圳北科生物科技有限公司研发部总监、IPS首席科学家。

李陶在Science、Cell Stem Cell等国际学术刊物上发表30多篇原创论文，其中影响因子5.0以上的文章近20篇，在Science上发表的论文影响因子达到31.9，发明专利9项。

科研成果

1.Tao Li, Ji-Fan Hu, Jianqun Ling, Thanh H. Vu, Andrew R. Hoffman. AberrantIGF2imprinting in human malignancy is associated with the altered CTCF-PRC2-IGF2 promoter intrachromosomal loop complex. in preparation.

2.Tao Li, Ji-Fan Hu, Xinwen Qiu, Jianqun Ling, Huiling Chen, Shukui Wang, Aiju Hou, Thanh H. Vu, Andrew R. Hoffman. CTCF regulates allelic expression ofIgf2by orchestrating a promoter-polycomb repressive complex-2 intrachromosomal loop.Proc Natl Acad Sci U S A, in press.（Sci, 10.5）

3.Theresa L. Chen,Wen-Jun Shen, Xin-Wen Qiu,Tao Li,Andrew R. Hoffman and Fredric B. Kraemer (2007). Generation of novel adipocyte monolayer cultures from embryonic stem cell. Stem cells and Development, 16:371–380.

4.Hui Ling Chen*,Tao Li* (*并列第一作者),Xin Wen Qiu, JieWu, Jian Qun Ling, Zhi Hong Sun, Weibo Wang, Wei Chen, Aiju Hou, Thanh H Vu, Andrew R Hoffman and Ji-Fan Hu (2006). Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming.The EMBO Journal25, 5329–5338. （Sci, 10.5）

5.Jianqun Ling,Tao Li, Ji Fan Hu,1 Thanh H. Vu, Hui Ling Chen, Xin Wen Qiu, Athena M. Cherry, Andrew R. Hoffman (2006). CTCF Mediates Interchromosomal Colocalization Between Igf2/H19 and Wsb1/Nf1.ScienceVol. 312: 269-272. （Sci, 31.9）

6.Tao Li, Thanh H.Vu, Gary A.Ulaner, Eva Littman, Jian-Qun Ling, Hui-Ling Chen, Ji-Fan Hu, Barry Behr, Linda Giudice and Andrew R. Hoffman (2005). IVF results inde novoDNA methylation and histone methylation at anIgf2-H19imprinting epigenetic switch.Mol Hum Reprod11(9): 631-640.（Sci, 3.1）

7.Thanh H Vu*,Tao Li*(*并列第一作者)and Andrew R Hoffman (2004). Promoter-specific histone code marks imprinting status of IGF2 receptor in human and mouse.Human Molecular Genetics13(19):2233-2245.（Sci, 7.8）

8.Xiaoming Yao, Ji-Fan Hu,Tao Li,Youwen Yang, Zhihong Sun, Gary Ulaner, Thanh H Vu, and Andrew R. Hoffman (2004). Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors.Cancer Genetics and Cytogenetics. 151(1):1-13.（Sci, 1.6）

9.Tao Li, Thanh H. Vu, Gary A. Ulaner, Youwen Yang, Ji-Fan Hu and Andrew R. Hoffman (2004). Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene.Human Molecular Genetics13: 741–750.（Sci, 7.8）

10.Youwen Yang, Ji-Fan Hu, Gary A. Ulaner,Tao Li, Xiaoming Yao, Thanh H. Vu, and Andrew R. Hoffman (2003). Epigenetic Regulation of Igf2/H19 Imprinting at CTCF Insulator Binding Sites.Journal of Cellular Biochemistry90:1038–1055. （Sci, 3.0）

11.Youwen Yang*,Tao Li*(*并列第一作者), Thanh H, Gary A. Ulaner, Jifan Hu and Andrew R. Hoffman (2003). The Histone Code Regulating Expression of the Imprinted MouseIgf2rGene.Endocrinology144:5658–5670.（Sci, 5.2）

12.Thanh H. Vu*,Tao Li*(*并列第一作者),Chuyen V. Nguyen and Andrew R. Hoffman (2003). Loss of Imprinting ofIGF2Sense and Antisense Transcripts in Wilms’ Tumor.Cancer Research63: 1900–1905.（Sci, 7.7）

13.Xiaoming Yao, Ji-Fan Hu, Mark Daniels, Huifan Yien, Hongqi Lu, Hadas Sharan, Xiangjun Zhou, Zhilan Zeng,Tao Li, Youwen Yang, and Andrew R. Hoffman (2003). A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis.Clinical Cancer Research. 9:2719-2726.（Sci, 5.6）

14.Gary A. Ulaner, Thanh H. Vu,Tao Li, Ji-Fan Hu1, Xiao-Ming Yao, Youwen Yang, Richard Gorlick, Paul Meyers, John Healey, Marc Ladanyi and Andrew R. Hoffman (2003). Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site.Human Molecular Genetics12: 535–549.（Sci, 7.8）

15.Xiaoming Yao, Ji-Fan Hu, Mark Daniels, Xingjun Zhou, Huifan Yien, Hongqi Lu, Zhilan Zeng, Tao Li, and Andrew R. Hoffman (2002). A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma.J. Clin. Invest.111: 265–273.（Sci, 14.2）

16.Tao Li, Thanh H. Vu, Kok-Onn. Lee, Chuyen V. Nguyen , Huy Q. Bui, Zhi-Lan Zeng, Binh T. Nguyen, Ji-Fan Hu, Susan K. Murphy, Randy L. Jirtle, and Andrew R. Hoffman (2002). Imprinted PEG1/MEST Antisense Expressed Predominantly in Human Testis and in Mature Spermatozoa.Journal of Biological Chemistry16:13518-13527.（Sci, 6.4）

17.Killian JK, Nolan CM, Wylie AA,Li T, Vu TH, Hoffman AR, Jirtle RL (2001). Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary.Human Molecular Genetics10:1721-1728. （Sci, 7.8）

18.Tao Li,Thanh H. Vu, Danielle Nguyen, Binh T. Nguyen, Jifan Hu and Andrew Hoffman (2000). Tissue-specific expression of antisense and sense transcript at the imprinted Gnas locus.Genomics69: 295-304.（Sci, 3.8）

19.Ji-fan Hu, Jung Pham, Indiral Dey,Tao Li, Thanh H. Vu and Andrew R. Hoffman (2000). Allele-specific histone Acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene.Endocrinology. 141: 4428-35. （Sci, 5.2）

20.Tao Li, Thanh H. Vu, Danielle Nguyen, Binh T. Nguyen, Xiaoming Yao, Jifan Hu and Andrew Hoffman (2000). Symmetric and Asymmetric DNA methylation in the Human IGF2-H19 imprinted region.Genomics.64, 132-143.（Sci, 3.8）

21.Okamura K, Hagiwara-Takeuchi Y,Li T,Vu TH, Hirai M, Hattori M, Sakaki Y, Hoffman AR, Ito T. (2000). Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting.Genome Research. 10: 1878-1889.（Sci, 10.4）

22.Hu JF, Balaguru KA, Ivaturi RD, Oruganti H,Li T, Nguyen BT, Vu TH and Hoffman AR (1999). Lack of reciprocal genomic imprinting of sense and antisense RNA of mouse insulin-like growth factor II receptor in the central nervous system.Biochem Biophys Res Commun. 257: 604-608.（Sci, 2.9）

部分专利

细胞转核诱导体细胞成多能二倍体干细胞的方法

单个核细胞培养液 Mononuclear cell culture medium

通过mRNA诱导体细胞为多能干细胞的方法

一种高效诱导人类体细胞重编程为多潜能干细胞的方法

一种可用于肝衰竭治疗的经HGF基因修饰的UCMSC制备方法

牙齿来源间充质干细胞体外分离与培养方法

一种用于免疫治疗的EB病毒LMP2A串联表位肽及其应用